The vaccine has passed its Phase 1 human trials with success.
The long-term immune responses indicated the vaccine's effect is long-lasting. One year following vaccination, seven of the patients who recieved middle- or high-doses returned to the lab for an additional follow-up test. Six of them had neutralizing antibody levels over the protective threshold. This proves that the immune response from the vaccine is persistent.
"We’re absolutely delighted with these early results – the vaccine has performed even better than we had expected. The problems with existing rabies vaccines are that they are expensive and require multiple doses.
The next plan of the researchers is to further develop the vaccine in light of the promising results from the RAB001 trial and pave the way for larger-scale clinical trials. Currently, the team is conducting the Phase Ib/II clinical trial in Tanzania to evaluate safety and immunogenicity; findings from that trial are anticipated later this year, with final results due by the end of 2023.Rabies kills around 60 000 people each year. ChAdOx2 RabG, a simian adenovirus-vectored rabies vaccine candidate, might have potential to provide low-cost single-dose pre-exposure rabies prophylaxis.
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