A significant proportion of patients developed exocrine pancreatic insufficiency 12 months after a diagnosis of acute pancreatitis, according to a large prospective study.
Over one third of patients with acute pancreatitis develop exocrine pancreatic insufficiency at 12 months, with the key predictors being idiopathic etiology, moderately severe or severe disease, and preexisting diabetes.EPI has traditionally been associated with chronic pancreatitis , but its prevalence and natural history following acute pancreatitis are less well defined.
Researchers conducted a prospective cohort study including 85 hospital inpatients diagnosed with acute pancreatitis from three tertiary institutions in the United States.EPI was assessed by measuring fecal elastase 1 levels from stool samples at baseline and at 3 and 12 months after enrollment. EPI was defined by FE-1 levels ≤ 200 μg/g stool, with mild and severe EPI categorized by FE-1 levels of 101-200 μg/g stool and ≤ 100 μg/g stool, respectively.
The prevalence of EPI was assessed at 3 and 12 months after acute pancreatitis. The study also identified the predictors of EPI, including the role of etiology and severity of acute pancreatitis and preexisting diabetes.EPI was present in 34.1% participants at 12 months after an acute pancreatitis attack, with 22.4% having severe EPI.=.031).
The prevalence of severe EPI after acute pancreatitis decreased from 29% at baseline to 26% at 3 months and 22% at 12 months."While specific subpopulations may have identified clinical risk factors, it will remain important to have a low threshold for testing and treatment as there remains much to learn about mechanisms leading to EPI after ," the authors wrote.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Abdominal Infection Acute Pancreatitis Chronic Pancreatitis Exocrine Pancreatic Insufficiency EPI - Exocrine Pancreatic Insufficiency Hospitals
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