Polyunsaturated fatty acids may have a favorable effect on disease progression and survival for patients with ALS.
Previous studies have shown that a diet high in ALA and increased blood levels of this fatty acid may decrease the risk of ALS, but less is known about how PUFAs affect disease progression.
After adjusting for age and sex, higher plasma levels of ALA were associated with a lower risk of death , as well as a higher joint-rank test score consistent with slower functional decline The results were similar when adjusted for body mass index, race/ethnicity, symptom duration, site of onset, use ofHigher levels of EPA and LA were also associated with a lower risk of death during follow-up.
"There are no immediate clinical implications. We need to conduct a randomized trial testing whether ALA is beneficial in people with ALS before we can recommend supplements to patients," he added., Stephen Scelsa, MD, director of the ALS Center, Mount Sinai Downtown Union Square, New York, said when it comes to nutrition in ALS,"we don't have great data.
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