High-definition cathodal transcranial direct current stimulation is a promising approach for treating acute ischemic stroke, results of a pilot study suggest.
"Treatments for AIS are currently limited to reperfusion therapies: intravenous thrombolysis and endovascular thrombectomy," the authors write.patients are not candidates for the two main treatments and even among those eligible for those treatments, only an estimated 20% to 30% are disability free 3 months after stroke," Bahr-Hosseini said.
Moreover, C-tDCS is"regionally directed therapy that instantly reaches maximum local concentration" and can be"tailored to the ischemic tissue at risk of infarction." Two doses of HD C-tDCS were studied: 1 milliamp [mA] for 20 minutes and 2 mA for 20 minutes . The first four patients were enrolled at tier 1, while the subsequent six were enrolled at tier 2."The primary tolerability endpoint was met, with all patients completing the assigned stimulation period," the authors report. No discoloration or rash was detected by the technician on visual inspection following stimulation.
The quantitative relative cerebral blood volume change in early poststimulation was a median of 64% in active vs −4% in sham patients and"followed a dose-response pattern."These findings"indicate a possibly true biological effect of the treatment," Bahr-Husseini said. Although there has been evidence supporting tDCS in animal models of stroke, demonstrating the potential value of this treatment in human patients with acute ischemic stroke is"very important" and has"clear implications, although it was an exploratory study in a small number of patients," said Liu, who was not involved with the study.
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