In addition to the 24% average weight loss on the highest dose in the trial – about 58 pounds over 11 months – a quarter of patients on that dose experienced weight loss of at least 30%.
An experimental drug from Eli Lilly helped patients with obesity lose an average of 24% of their body weight over 48 weeks on the highest dose in a mid-stage study, the most weight loss seen yet in a new class of drugs that’s revolutionizing the field.
Retatrutide adds yet a third target, glucagon, giving it the moniker “triple G.” In this mid-stage trial, Lilly enrolled about 340 adults with obesity, who had a body mass index of at least 30. The trial also included about 4% of patients with a BMI of between 27 and 30, in the overweight category, with at least one weight-related health condition.
About 7% of patients on the drug experienced skin tingling, the researchers reported, compared with 1% on placebo. One patient had elevated liver enzymes, and one had a case of acute pancreatitis, or inflammation of the pancreas. Increases in heart rate were seen up until 24 weeks in patients on the medicine, and then decreased, the study showed, although one patient had a severe adverse heart event known as prolonged QT syndrome.
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