Eli Lilly's drug donanemab appeared to slow down the rate of cognitive decline in patients by 35% compared to placebo.
on the coverage of these antibody-based drugs, one still in place today. This policy mandates that people on Medicare can only receive coverage for Aduhelm and similar drugs given an accelerated approval in a context of a clinical trial or other type of approved study. It does provide broader coverage for drugs granted a typical approval, however. Eli Lilly hadfor an accelerated approval of donanemab in January but was denied by the FDA.
While the presented results are the best for this drug class so far, they haven’t been vetted yet by outside scientists, an important part of the scientific process. The real-world impact of donanemab also remains to be seen. Many experts have expected lecanemab to only provide a modest delay of Alzheimer’s progression, perhaps only amounting to a few extra months.Another concern is the drug’s side effects.
but at least two patients are believed to have died as a result, with a third death inconclusively linked to the side effect . These side effects may still be outweighed by the clinical benefits provided by donanemab, especially given that Alzheimer’s disease is currently 100% fatal. Perhaps the most important aspect here is the continued, if incremental, improvements we’re now seeing with experimental Alzheimer’s drugs. On their own, the current and upcoming generation of anti-plaque drugs will likely not cure Alzheimer’s.
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