Biologists are reaping a scientific bonanza from recent techniques that let them study the genetics of just one cell at a time. By borenbears.
A scientist at the NY Genome Center in New York demonstrates equipment used in single-cell RNA analysis on Wednesday, Sept. 26, 2018. Until recently, trying to study key traits of cells from people and other animals often meant analyzing bulk samples of tissue, producing an average of results from many cell types. But scientists have developed techniques that let them directly study the DNA codes, and its chemical cousin RNA, the activity of genes and other traits of individual cells.
Because it shows averages can be misleading. And Smibert, of the New York Genome Center, says that includes when scientists are trying to understand the basic unit of life, the cell. “Single-cell analysis is crucial for a comprehensive understanding of our biology and health,” Dr. Francis Collins, the director of the National Institutes of Health, declared recently.
— Other researchers revealed details of the physical connection between pregnant women and the fetus, giving potential clues for understanding some causes of stillbirth. The discovery offers great potential for guiding the development of new treatments, said Dr. William Skach, senior vice president of research affairs for the Cystic Fibrosis Foundation. Single-cell techniques will be important in studying them further for coming up with new therapies, he said. .
Why do this? It’s a natural follow to the big project that catalogued all the human genes, says co-organizer Aviv Regev, a biology professor at the Massachusetts Institute of Technology and researcher at the Broad Institute of MIT and Harvard.
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