New study on the genetic magnetization of living bacteria shows great potential for biomedicine

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New study on the genetic magnetization of living bacteria shows great potential for biomedicine
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Magnetic bacteria possess extraordinary capabilities due to the magnetic nanoparticles, the magnetosomes, which are concatenated inside their cells. A research team at the University of Bayreuth has now transferred all of the approximately 30 genes responsible for the production of these particles to non-magnetic bacteria in a broad series of experiments.

This resulted in a number of new bacterial strains that are now capable of producing magnetosomes. The research findings presented inare groundbreaking for the generation of magnetized living cells, which have great potential for the development of innovative diagnostic and therapeutic methods in biomedicine.

Magnetization was successful in seven species: these bacteria continuously produce magnetosomes in which iron-containing magnetite crystals are chained together in a manner similar to that in the donor bacterium Magnetospirillum gryphiswaldense. "According to the current state of research, they are well compatible with human cells. This opens up new perspectives for a variety of biomedical applications—for example, for microrobot-controlled transport of active pharmaceutical ingredients, for magnetic imaging techniques, or even for optimizations of hyperthermia cancer therapy," says the first author of the new study, Dr. Marina Dziuba, who is a research associate at the Microbiology research group in Bayreuth.

Comparison between the genome of these strains and the genome of those genetically modified bacteria that failed to produce magnetosomes has also led to valuable insights. There is much evidence to suggest that the magnetosome formation of transgenic bacterial strains is closely related to their ability to photosynthesize or to engage in oxygen-independent, so-called anaerobic respiration processes.that transgenic bacteria lack when they are incapable of magnetosome formation.

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