Scientists have captured the fleeting moment when a heart starts beating, a feat made all the more remarkable when you consider the relative brevity of a zebrafish's life.
In a tight window about 20 hours into zebrafish development, the embryos' developing hearts jumped into action, emerging as one from an ensemble of single cells.Harvard University biophysicist Adam Cohen, senior author of the new study, which imaged zebrafish embryos snug in custom-made agarose molds to capture this once-in-a-lifetime event.
From past studies, it has become clear that the first heartbeat occurs even before the first heart structure, a primitive tube, forms.
Interestingly, the surging waves of calcium ions preceding the first heartbeat didn't always originate in the same place in different zebrafish embryos, suggesting that there's nothing unique about the cells that fire first. Jia and co. think that the early activity in heart cells, before the first contraction, might stimulate cardiovascular development.
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