The notion of depression as abnormal brain activity rather than a chemical imbalance led to the development of deep brain stimulation as a depression treatment.
For most medical conditions, doctors can directly measure the part of the body that is being treated, such as blood pressure for cardiovascular disease. These measurable changes serve as an objective biomarker of recovery that provides valuable information about how to care for these patients.that ask patients about their symptoms.
Our research team wanted to find specific changes in brain activity that could serve as a biomarker that objectively measures how well deep brain stimulation is helping patients with depression. So weAt the end of six months, 90% of the patients responded to the therapy — defined by a reduction of symptoms by at least a half — and 70% were in remission, meaning they no longer met the criteria for clinical depression.
For another example, we found that the facial expressions of patients changed as their brains changed over the course of their treatment. While physicians often report this anecdotally, quantifying these changes may provide a way to develop objective markers of recovery that incorporate a patient’s behavior with their brain signals.
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