A new tool to track the neurons and molecules activated in the brain by psychedlic drugs could help scientists unlock the benefits of psychedelic treatments for patients with brain disorders.
Researchers at the University of California, Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs . The protein-based tool, which is called CaThere has been mounting interest in the value of psychedelic-inspired compounds as treatments for brain disorders including depression, post-traumatic stress disorder and substance use disorder.
"We designed these proteins in the lab that can be packaged into DNA and then put into harmless adeno-associated viruses," Kim said."Once we deliver the CaST tool and these proteins into neurons, then they incubate inside the cells and start expressing." The researchers also monitoring the head-twitch responses in the mice. Head-twitch responses are the primary behavioral correlate for hallucinations caused by psychedelics.
The goal is to identify how psychedelics benefit the cellular profiles of those with brain disorders, elucidating the step-by-step cellular process of their therapeutic effects. Additional UC Davis authors on the study include lead authors Run Zhang and Maribel Anguiano, and Isak K. Aarrestad, Sophia Lin, Joshua Chandra and Sruti S. Vadde.
Psychology Research Brain Tumor Accident And Trauma Psychedelic Drugs Neuroscience Brain Injury Disorders And Syndromes
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