In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.
New gene delivery vehicle shows promise for human brain gene therapy ." ScienceDaily. ScienceDaily, 16 May 2024. <www.sciencedaily.comBroad Institute of MIT and Harvard. . New gene delivery vehicle shows promise for human brain gene therapy .
In the first in-human clinical trial, scientists used a novel, skull-implantable ultrasound device to open the blood-brain barrier and repeatedly permeate large, critical regions of the human brain ... The blood-brain barrier is an imposing foe for gene therapy. Formed of cells wedged tightly together, the BBB keeps toxins and pathogens that may be present in the blood from entering brain ...
A new study not only sheds light on how the APOE4 gene may cause some of the pathologies associated with Alzheimer's disease, but also suggests a new treatment target that might help people who carry ... The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a new study, researchers found that the spike protein, often depicted as the red arms of the virus, can cross the ...AI Systems Are Already Skilled at Deceiving and Manipulating Humans
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