A vaccine that blocks fentanyl from entering the brain in rats – thus stopping the addictive high – could one day be used to combat the opioid crisis.
Importantly, the vaccine did not block the action of other, non-fentanyl opioids, suggesting that it may not prevent pain relief for humans via other means.
"We believe these findings could have a significant impact on a very serious problem plaguing society for years – opioid misuse,"In the study, researchers gave rats three doses of the fentanyl vaccine at three-week intervals. Another group of rats received a placebo.levels over time in the vaccinated rats.
In another experiment, they exposed the rats to a hotplate and timed how long it took them to lick their hind limbs. The vaccinated rats pulled away from painful stimuli faster than the control group in both experiments, showing that the vaccine – when administered at the higher of two doses – was blocking the painkiller effect of fentanyl."Our vaccine is able to generate anti-fentanyl
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