Neurons in a Dish Learn to Play Pong

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Neurons in a Dish Learn to Play Pong
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A cellular version of the computer game challenges assumptions about intelligence

Hundreds of thousands of human neurons growing in a dish coated with electrodes have been taught to play a version of the classic computer game Pong.

Intelligence in a dish The work is a proof of principle that neurons in a dish can learn and exhibit basic signs of intelligence, says lead author Brett Kagan, chief scientific officer at Cortical Labs in Melbourne, Australia. “In current textbooks, neurons are thought of predominantly in terms of their implications for human or animal biology,” he says.

The work from Cortical Labs brings more-sophisticated technology and analytical tools to bear, says Potter. His original dishes had dozens of electrodes; each DishBrain has thousands. Potter’s group studied only rodent cells, but the DishBrain team also tested neurons derived from human cells. To teach the neurons to hit the ball, Kagan says, he and his team harnessed the theory that neurons tend to repeat activity that yields a predictable environment. When the neurons responded in a way that corresponded with hitting the ball, they were stimulated in a location and at a frequency that was the same each time. If they missed the ball, the network was stimulated by the electrodes in random locations and at different frequencies.

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