Nature research paper: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE
, yet developmental signals shaping their longevity remain largely unknown. Here we demonstrated in mice genetically deficient in 12/15-LOX that neonatal neutrophil-derived 12-HETE was required for self-renewal and maintenance of alveolar macrophages during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction of AM in the adult lungs and enhanced senescence due to increased prostaglandin E production.
Department of Medicine, Meakins-Christie Laboratories, Research Institute McGill University Health Centre, McGill University, Montreal, Quebec, Canada Erwan Pernet, Nargis Khan, Kim A. Tran, Julia Chronopoulos, Dnyandeo Amberkar, Shradha Wali, Renaud Prevel, Jun Ding, James G. Martin & Maziar DivangahiSarah Sun, Saideep Gona & Luis B. Barreiro
Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases and Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, CanadaDepartment of Microbiology & Immunology, Meakins-Christie Laboratories, Research Institute McGill University Health Centre, McGill University, Montreal, Quebec, CanadaDepartment of Genetics, CHU Sainte-Justine Research Center, Montreal,...
Indonesia Berita Terbaru, Indonesia Berita utama
Similar News:Anda juga dapat membaca berita serupa dengan ini yang kami kumpulkan dari sumber berita lain.
Wild weather driven by roiling Pacific, nature and warmingIn a world getting used to extreme weather, 2023 is starting out more bonkers than ever and meteorologists are saying it’s natural weather weirdness with a bit of help from human-caused climate change. Much of what’s causing problems worldwide is coming out of a roiling Pacific Ocean, transported by a wavy jet stream, experts said. At least one highway in drought-mired California looked more like a river because of torrential rain from what is technically called an atmospheric river of moisture.
Baca lebih lajut »
Cost-effective mitigation of nitrogen pollution from global croplands - NatureA meta-analysis of 1,521 field observations from the past two decades led to the identification of 11 key measures to cost-effectively mitigate nitrogen pollution from global croplands.
Baca lebih lajut »
Papers and patents are becoming less disruptive over time - NatureA decline in disruptive science and technology over time is reported, representing a substantive shift in science and technology, which is attributed in part to the reliance on a narrower set of existing knowledge.
Baca lebih lajut »
Natural education: Support grows for nature preschools after learning model blossomed amid pandemicSurging interest in outdoor schooling comes amid multiple reports showing U.S. test scores dropped dramatically as students switched to virtual and hybrid learning during the pandemic.
Baca lebih lajut »
Nature’s Soundtrack Reveals the Secrets of Degradation'Hey. Siri. Play nature's soundtracks.' Researchers are applying digital listening technology to the natural world. It turns out it has quite a lot to say to us—and not all of it sounds good.
Baca lebih lajut »