British researchers reported a breakthrough Monday in mysterious hepatitis cases affecting young children, finding the serious liver condition was linked to co-infection of two common viruses, but not the coronavirus.
The two studies looked both at patients who acquired hepatitis and those that did not, finding that AAV2 was mostly present in those who got the illness, not those that didn't.further tested genes of children who had become sick and those that didn't, honing in on differences in their Human Leukocyte Antigen that might explain why some are more susceptible than others.
It is unclear why hepatitis cases spiked recently, but both teams underscored the possibility that lockdowns could have contributed, either by lowering immunity in children or by changing the patterns of virus circulation.Deirdre Kelly, a professor of pediatric hepatology at the University of Birmingham who was not involved in the work, said:"I think this is a plausible explanation for these cases. It looks like coinfection is the key.
But, she added, more work was needed to understand why some children develop severe disease and require transplantation.it was also important"to understand more about seasonal circulation of AAV2, a virus that is not routinely monitored". "It may be that a peak of adenovirus infection has coincided with a peak in AAV2 exposure, leading to an unusual manifestation of hepatitis in susceptible young children."
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