Research shows new mRNA vaccine technology could help researchers save millions of lives, prevent illness, and make progress toward the elimination of this ancient disease. Found in more than 90 countries around the world, malaria causes 241 million cases and an estimated 627,000 deaths every yea
are responsible for more than 90% of all malaria cases globally, and 95% of all malaria deaths. Most cases and deaths occur in sub-Saharan Africa but half the world’s population is at risk of contracting this deadly disease. Kumar’s team developed two mRNA vaccines to disrupt different parts of the parasite’s life cycle.
The study found both vaccines induced a potent immune response in the mice and were highly effective in reducing infection in the host and in the mosquito vector. The presence of protective antibodies during transmission of parasites to healthy mosquitoes dramatically reduced the parasite load in the mosquitoes, an important step in disrupting malaria transmission, according to the researchers.
The team also immunized mice with both vaccines together and found that co-immunization effectively reduced infection and transmission without compromising the immune response.-based vaccine platforms, Kumar and the team repeated the experiment usingplasmids. The mRNA vaccines were far superior in inducing an immune response compared to the DNA-based vaccines, they found.
“To have a vaccine cocktail that can effectively disrupt multiple parts of the malaria parasite’s life cycle is one of the holy grails of malaria vaccine development,” Kumar said. “This study brings us one step closer to producing vaccines that can be used safely in humans to prevent illness, save lives–with the ultimate goal of defeating this disease.”
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