The SGLT inhibitor empagliflozin significantly slowed progression of renal dysfunction or death from cardiovascular causes among patients with CKD who did not have diabetes or heart failure. KidneyWk
The results were simultaneouslyIn 2020, a different team of researchers running DAPA-CKD reported that during a median of 2.4 years, treatment of 4304 patients with dapagliflozin 10 mg daily resulted in a significant 39% relative risk reduction compared with placebo for an identical combined primary endpoint. Enrollment criteria for the DAPA-CKD trial were mostly similar to that of the current trial.
In addition to cardiovascular death, the combined primary endpoint included the incidence of renal death, incident end-stage kidney disease, a sustained decrease in estimated glomerular filtration rate to less than 10 mL/min/1.
In contrast, to enroll in DAPA-CKD, patients had to have a UACR of at least 200 mg/g. This means that for the first time, EMPA-Kidney produced data on the relationship between albuminuria severity and the impact of treatment with an SGLT2 inhibitor in the enrolled population.A total of 6609 patients underwent randomization in EMPA-Kidney. During a median of 2.
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