Eli Lily reported that the drug helped people with diabetes who were overweight or had obesity lose up to 16% of their body weight over 17 months in a late-stage trial.
As a growing number of overweight Americans clamor for Ozempic and Wegovy -- drugs touted by celebrities and on TikTok to pare pounds -- an even more powerful obesity medicine is poised to upend treatment.
Based on the new results, which have not yet been published in full, company officials said they will finalize an application to the U.S. Food and Drug Administration for fast-track approval to sell tirzepatide for chronic weight management. A decision could come later this year. A company spokeswoman would not confirm whether the drug would be marketed for weight loss in the U.S. under a different brand name.
In separate trials, tirzepatide has resulted in greater weight loss than semaglutide, whose users shed about 15% of their body weight over 16 months. A head-to-head trial comparing the two drugs is planned. Rather than relying solely on diet, exercise and willpower to reduce weight, tirzepatide and other new drugs target the digestive and chemical pathways that underlie obesity, suppressing appetite and blunting cravings for food.
"That is a real physical phenomenon," Aronne said. "There are a number of hormones that respond to reduced calorie intake."
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