At Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 are dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated.
For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women, Computerworld magazine’s list of 100 Best Places to Work in Information Technology, DiversityInc Top Hospitals & Health Systems and continually named one of the Tampa Bay Time’s Top Workplace. Additionally, Moffitt is proud to have earned the prestigious Magnet® designation in recognition of its nursing excellence.
The research interest of the lab is to study the structures, regulation, and therapeutic targeting of p53 tumor suppressor pathway for cancer treatment. Ongoing work involves development of novel PROTACs, targeting of temperature-sensitive mutant p53, transcription potential of mutant p53, MDMX regulation of Wnt signaling. Link to publications from Dr. Chen’s lab:
Extensive collaborations with chemists and structural biologists working in drug discovery, providing a rich environment for training and career development. Outstanding mentorship from expert faculty with wide-ranging funded research programs including T32 Training Grants.Experience with mouse tumor xenograft models or genetically modified mouse models.Competent in cell culture, protein analysis, CRISPR and recombinant DNA techniques.Plans and performs experiments directed towards answering specific scientific questions with limited supervision under the general guidance of Investigator.
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