A large genomic analysis suggests migraines and blood sugar-related conditions have a shared genetic basis.
For someone prone to migraines, a missed meal could be a fast-track to an attack. Out-of-balance blood sugar is a well-established trigger for migraines and other types of headaches. Now, a new study adds genetic evidence to back up the connection and could potentially inform future strategies for treating migraines.
Migraines affect almost 15% of people worldwide and are three times more common in women than in men, according to the World Health Organization . They can be set off by many different triggers, such as hormonal fluctuations, lack of sleep and even certain foods. But researchers still don't fully understand why some people are prone to frequent migraines. Some scientists are sifting through the genome for clues, hunting for genetic risk factors and links to other medical conditions.
By comparing those datasets, the team identified regions of the genome that appear to affect both blood sugar regulation and migraine risk.—A common food additive is linked to insulin resistance. Here's what that meansOne blood sugar measure that stood out was fasting proinsulin, which was actually linked to a reduced risk of migraine, said study coauthor Rafiqul Islam , a graduate student in the lab of Dale Nyholt at Queensland University of Technology in Australia.
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