Men have a significantly higher risk of developing 11 types of cancer compared to women. New research shows that the difference can be partly explained by risky behavior and carcinogenic exposure.
Men have a significantly increased risk than women of developing 11 different cancers, and the risk is three times greater for men for certain cancers, including those of the esophagus, larynx, gastric cardia, and bladder.
"This suggests that there are intrinsic biological differences between men and women that affect susceptibility to cancer," she added in a statement."Understanding the sex-related biologic mechanisms that lead to the male predominance of cancer at shared anatomic sites could have important implications for etiology and prevention," the researchers suggest.
This study"has furthered our understanding on sex disparities in cancer, particularly in terms of the contributions of risk factors.", hypercholesterolemia, and cardiovascular disease, the study has some"pertinent" limitations, they comment. "Strategically including sex as a biologic variable should be enforced along the whole cancer continuum, from risk prediction and cancer primary prevention, cancer screening, and secondary prevention to cancer treatment and patient management," Luo and Colditz conclude.In their paper, Jackson and colleagues point out that the lifetime probability of developing cancer is"approximately equal" in men and women, at 40% vs 39%.
The current study focused on 334,905 participants who also completed a follow-up questionnaire between 1996 and 1997, which included more detailed information on diet and other lifestyle factors.
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