Lewy body disease ranks as the second most prevalent neurodegenerative disorder, following Alzheimer's disease. A team of researchers from Lund University has now determined that the disease can be identified prior to the onset of symptoms through a spinal fluid test. The studies are published in Na
has now determined that the disease can be identified prior to the onset of symptoms through a spinal fluid test. The studies are published in, where the researchers also demonstrate that a reduced sense of smell is strongly linked to Lewy body disease even before other clear symptoms have developed. The findings are also reported simultaneously at the Alzheimer’s Association International Conference.
Until very recently, it was not possible to determine with certainty, whether a person with movement difficulties or cognitive impairments had Lewy bodies in the brain until after their death. But now, with a spinal fluid test, it is possible to see if the person has the misfolded protein. Oskar Hansson’s research group has just completed a large study involving over 1,100 individuals, none of whom initially showed any cognitive impairments or motor difficulties.
”Several drugs targeted at Lewy bodies are currently being developed, with the hope of slowing down the disease. Most likely, this type of medication has the best chance of being effective if administered early in the course of the disease. If symptom-free individuals with reduced sense of smell were identified, and the test for Lewy bodies was positive, they could participate in drug trials aimed at developing new medications that can halt the disease early,” says Oskar Hansson.
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