Researchers provide an important clue to Long Covid, finding viral proteins in the blood of 25% of people more than a year after infection.
These proteins in the blood indicate that SARS-CoV-2 keeps living in tissue reservoirs.viral proteins in the blood of 25 percent of patients, even up to 14 months after the initial infection with SARS-CoV-2. This means that for some Long Covid patients, their symptoms could come from ongoing infection.
But it was only in the fall of 2020, as the world began to reopen, that the team began to wonder if the Covid virus could persist in the body long-term. “As the healthcare system reopened, a lot of medical procedures required a Covid test. We began seeing a huge number of people who had what were thought to be either false positive Covid tests or reinfections. But when we tried to work them up, none of them were reinfections. Nobody really knew what was going on,” says Peluso.
According to Peluso, this single-molecule array is a type of immune assay. Because such immune-based assays are less specific than the commonly used PCR, some skeptics concluded that the prior studies were detecting false positive signals.In order to prove that their findings were not a false positive signal, the team ran the same test on 250 samples collected from a mix of people in 2012-2019.
“The thing that I find so compelling about the data in this study is that there is a pretty striking relationship between how sick people were during their acute Covid infection and how likely they were to have evidence of antigen persistence,” says Peluso. “To a clinician like me, that is very convincing, because intuitively, it makes sense that people who perhaps have a higher burden of virus upfront would be more likely to have a virus that sticks around.
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