A novel hydrogel developed by Johns Hopkins University researchers cured 100% of mice with aggressive brain cancer by combining anticancer drugs and antibodies to target lingering cancer cells and trigger an immune response against glioblastoma. Medication delivered by a novel gel cured 100% of m
Researchers at Johns Hopkins University have developed a novel hydrogel that has successfully cured 100% of mice with aggressive brain cancer, specifically glioblastoma. The hydrogel combines an anticancer drug and an antibody, and is applied to the brain after the surgical removal of a tumor. This treatment reaches areas that surgery might miss and current drugs struggle to access, killing lingering cancer cells and suppressing tumor growth.
“Despite recent technological advancements, there is a dire need for new treatment strategies,” said Honggang Cui, achemical and biomolecular engineer who led the research. “We think this hydrogel will be the future and will supplement current treatments for brain cancer.” “The surgery likely alleviates some of that pressure and allows more time for the gel to activate the immune system to fight the cancer cells,” Cui said.
By using that specific antibody, the team is trying to overcome one of the toughest hurdles in glioblastoma research. It targets macrophages, a type of cell that sometimes supports immunity but other times protects cancer cells, allowing aggressive tumor growth. “We don’t usually see 100% survival in mouse models of this disease,” Tyler said. “Thinking that there is potential for this new hydrogel combination to change that survival curve for glioblastoma patients is very exciting.”
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