“It’s pretty clear that the virus continues to evolve and going forward there is a need for a universal COVID-19 vaccine or even a universal coronavirus vaccine.”
the vaccine’s ability to generate antibodies that neutralize and block the entry of SARS-CoV and SARS-CoV-2 and its major variants into animal cells.
Björkman and her colleagues, on the other hand, are focusing on a more specific target: the spike protein’s receptor-binding domain . It’s the region of the spike to which most antibodies bind to prevent SARS-CoV-2 from entering the host cell; it is also the region within which mutations occur, giving rise to variants.
several bat and human coronaviruses, including SARS-CoV-2 variants. A closer look revealed the antibody bound to the same small section of the spike protein’s RBD in different coronaviruses, which became the vaccine target.
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