An international study has identified more than 50 genes on the X chromosome in which mutations may cause poor sperm production
Nearly half of all men with low or zero sperm count have no medical explanation for their infertility. In the past few years, studies have identified three X chromosome genes that could be involved in sperm production issues. Butat the University of Florence in Italy wondered if there might be other genes on the X chromosome that play a role.
Most of the mutations in these genes affected the way the men’s testicular cells divide to make sperm cells, and the researchers found them repeatedly in these men – as well as in some infertile male flies and mice. “People often think about the X chromosome as a female chromosome, because females have two X chromosomes,” she says. “So initially, no one was really thinking that the X chromosome could be so [involved] in male [reproductive] fitness. But [our findings] are fitting with the theory that the X chromosome is important for male reproduction.”
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