The Washington University in St. Louis team used non-invasive ultrasound to stimulate the hypothalamus preoptic area of the brain. Find out more at 🚀 engineering interestingengineering
When stimulated in mice, it showed a nearly 3-degree Celsius drop in body temperature for an hour. Furthermore, the mice's metabolism for energy consumption switched from using both carbohydrates and fat to only relying on fat — one of the critical characteristics of achieving torpor. During this state, their heart rates also decreased by 47 percent.
“We developed an automatic closed-loop feedback controller to achieve long-duration and stable ultrasound-induced hypothermia and hypometabolism by controlling of the ultrasound output,” explained Hong Chen, an associate professor at the university, in an“The closed-loop feedback controller set the desired body temperature to be lower than 34 C, previously reported as critical for natural torpor in mice. This feedback-controlled UIH kept the mouse body temperature at 32.
Through genetic sequencing, they found that ultrasound activated the "TRPM2 ion channel" in the hypothalamus preoptic area neurons.
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