Nature - <ArticleTitle Language="En" xml:lang="en">Human genetic and immunological determinants of critical COVID-19...
10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in1.5 times greater in men than in women. What are the molecular and cellular determinants of critical COVID-19 pneumonia? Inborn errors of type I IFNs, including autosomal TLR3 and X-linked TLR7 deficiencies, are found in1-5% of patients with critical pneumonia under 60 years old, and a lower proportion in older patients.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USADepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, NetherlandsSt.
Anne Puel, Bertrand Boisson, Emmanuelle Jouanguy, Jacinta Bustamantem, Shen-Ying Zhang, Stephanie Boisson-Dupuis & Vivien BeziatAnne Puel, Bertrand Boisson, Emmanuelle Jouanguy, Jacinta Bustamantem, Shen-Ying Zhang, Stephanie Boisson-Dupuis & Vivien Beziat Benedetta Bigio, Jie Chen, Juan Li, Marcela Moncada-Velez, Masato Ogishi, Natalie Alexander, Peng Zhang, Rui Yang & Takaki AsanoLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, FranceGrupo de Inmunodeficiencias Primarias, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia UDEA, Medellín, ColombiaResearch Unit, Hospital Universitario Nuestra Señora de...
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