The world No. 1 takes on Spain's Pablo Carreno Busta, while Medvedev plays Australia's Alexei Popyrin.
Nadal dispatched 76th-ranked Federico Delbonis of Argentina in the second round on Thursday, winning 6-3 7-6 6-1.
Nadal and Carreno Busta are due on court in the final match of the morning session, which should begin early in the afternoon local time . The Russian, who lost the 2019 U.S. Open final to Nadal, played under the roof at the Margaret Court Arena after a deluge fell on Melbourne and admitted adapting to different conditions was crucial to succeed at the Australian Open.
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