How to bring back the sense of smell

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How to bring back the sense of smell
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How researchers are tackling the problem of a loss of smell

“There are now millions of people around the world that still have persistent olfactory loss” after COVID-19, says Claire Hopkins, a rhinologist at King’s College London. “It is still very much a neglected area, both in terms of research funding and support from health-care systems, and it is dismissed in terms of the impact it has on people.”

COVID-19 has put the loss of smell in the spotlight as never before, highlighting both the unique regenerative capacity of the olfactory system and the need for better treatments. The virus has provided insights into the mechanisms behind losing the sense of smell, and has resulted in a large group of people with a persistent olfactory impairment who can take part in clinical trials of potential treatments.

Yet, despite increasing attention to smell loss from physicians and scientists, treatments for most forms of the condition are scarce. Loss of smell can be an early symptom of neurodegenerative diseases such as Parkinson’s disease or Alzheimer’s disease. There is no treatment for this form of smell loss, which probably involves the same mechanisms that cause damage elsewhere in the brain.

Olfactory training has its roots in the established understanding that the sense of smell is mutable and improvable.

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