How stem cells make a human brain

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How stem cells make a human brain
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Researchers hope that this study, and others like it, will illuminate how developmental programmes go awry in neurological diseases — and how they can be harnessed to create new therapies.

To understand how such cells arise, stem cell biologists Irving Weissman and Daniel Liu and their colleauges at Stanford University in California harnessed new technology that would allow them to study the developmental destiny of individual cells taken from human brains.

The researchers then injected the purified cells into mouse brains. Six months later, they analysed those mice to find out where the cells and their descendants had migrated, and what cellular identities they had taken. Such differences could also be the result of the new approach’s improved resolution of different cell types, Goldman says, adding that the work is “a technical tour de force. … They upped the level of the field.” Weissman says that the technique might be useful for studying other kinds of stem cell as well.The study is an important contribution to the growing knowledge of the cellular lineages that give rise to the human brain, agrees Kriegstein.

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