A special issue of the journal Brain Plasticity explores research on how exercise-induced activation of peripheral systems may improve cognitive function and delay or prevent the onset of neurodegenerative diseases. A growing body of research shows that exercise can enhance brain function and del
presents new research and insights on neural plasticity and the role of peripheral factors in cognitive health.
After each bout of exercise, blood samples were taken to measure circulating CTSB and BDNF, and CTSB protein, BDNF protein, and mRNA expression were measured in skeletal tissue. Scientists discovered that high-intensity exercise elevates circulating CTSB in young adults immediately after exercise, and that skeletal muscle tissue expresses both message and protein of CTSB and BDNF.
Five review articles cover interorgan crosstalk between muscle, liver, adipose tissue, the gut microbiome, and the brain. While it is well known that exercise protects the central nervous system, it has only recently been found to depend on the endocrine capacity of skeletal muscle. In their review, co-authors Mamta Rai, PhD, and Fabio Demontis, PhD, both of the Department of Developmental Neurobiology, St.
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