Here’s why pain might last after persistent urinary tract infections

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Here’s why pain might last after persistent urinary tract infections
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Experiments in mice reveal that the immune response to a UTI spurs nerve growth in the bladder and lowers the pain threshold.

Urinary tract infections are painful, inconvenient and incredibly common. For decades, doctors haven’t had any leads on why, even after several rounds of antibiotics, UTI pain can linger. Now they do.Understanding immune and nerve responses to persistent UTIs, the team says, could possibly lead to new, antibiotic-free forms of treatment. . The pain from these infections can be quite difficult to treat, says Marcus Drake, a neurological urologist at Imperial College London.

To better understand what was happening at the tissue level, the team induced multiple UTIs in mice. Compared with uninfected mice, “we saw a tremendous growth of nerves,” Abraham says. But that only confirmed what the team suspected about humans. The researchers still wanted to know what spurred the nerves to grow.

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