Some people who take the 5-day COVID-19 antiviral treatment are testing negative—then testing positive again days later
instructing doctors caring for patients who take the drug about how to manage rebound cases.
Paxlovid is a combination of two drugs: a protease inhibitor used to treat HIV infections that blocks the virus from making critical proteins it needs to replicate, and another that prevents the liver from breaking down the drug too quickly in the body. But Ho believes something else is going on. His small study showed that three of the infections in his report—his, Charness’, and that of one other person—were rebounds of the first, not new strains or a new Paxlovid-resistant variant. Based on the genetic sequencing data, “we showed the rebounding virus is not resistant to the protease inhibitor [drug in Paxlovid], because there is no change in protease sequence,” he says. “It’s notwith another virus. The sequences are identical.
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