The newly developed fiber-infused gel (FIG) ink allows the 3D-printed heart muscle cells to beat like a human heart chamber.
The fiber-infused gel ink allows the 3D-printed heart muscle cells to align and beat in coordination like a human heart chamber. The immediate goal of the researchers is to discover new therapeutics for heart disease, while the long-term plan is to fabricate implantable tissues.
“FIG ink is capable of flowing through the printing nozzle but, once the structure is printed, it maintains its 3D shape. Because of those properties, I found it’s possible to print a ventricle-like structure and other complex 3D shapes without using extra support materials or scaffolds,” Choi added.
Choi explains that the most challenging part of the process was maintaining the desired ratio between fibers and hydrogel in the ink. Once that was achieved, she applied electrical stimulation to 3D-printed structures made with FIG ink, which triggered a coordinated wave of contractions. “It was very exciting to see the chamber actually pumping in a similar way to how real heart ventricles pump,” said Choi.The study was published inHydrogels are attractive materials for tissue engineering, but efforts to date have shown limited ability to produce the microstructural features necessary to promote cellular self-organization into hierarchical three-dimensional organ models.
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