Groundbreaking mRNA Therapy Appears To Prevent and Treat Peanut Allergies in Mice

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Groundbreaking mRNA Therapy Appears To Prevent and Treat Peanut Allergies in Mice
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More treatments – and faster-acting treatments – for peanut allergies are urgently needed, and a new study outlines a promising drug technology based around a tiny nanoparticle just a few billionths of a meter in size.

In tests on mice, the nanoparticle reversed peanut allergies and prevented them from developing in the first place. If the same response is triggered in humans, it could change the lives of millions of people.; it's specially designed as an antigen that leaves out the part of the protein that normally causes the allergic reaction.

"If you're lucky enough to choose the correct epitope, there's an immune mechanism that puts a damper on reactions to all of the other fragments," By adding the mRNA element, the researchers could more easily load up the nanoparticle and fit it with multiple epitopes. The same approach is used inThe nanoparticle uses mRNA for encoding.

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