A UHN glioblastoma clinical trial shows the possibility of prolonged life in people with the aggressive brain cancer. — via healthing_ca BrainTumourFdn braincancercan healthing Glioblastoma: 'This type of cancer isn't fair'
in 2019 to collect data and support research. She lives with symptoms of fatigue and challenges with communication, planning and multitasking — and the uncertainty of her disease — while she waits for her next MRI to see if she’s in the clear.Cancerous brain tumours are complex and treatment-resistant, despite decades of laboratory and clinical studies. In fact, the last brain cancer breakthrough was the introduction of the chemotherapy drug temozolomide in 2005.
“Glioblastoma is the most aggressive brain cancer that exists. It’s one of the most deadliest cancers of the body,” says Dr. Farshad Nassiri, neurosurgery resident and scientist with the. He worked closely with lead author Dr. Gelareh Zadeh, neurosurgeon and co-director of the Krembil Brain Institute and senior scientist at Princess Margaret Cancer Centre.
Unfortunately, even with aggressive intervention, he says the tumour typically recurs and there’s not an alternative course of treatment.While immunotherapy has revolutionized the treatment of some cancers, working to turn off the cancer cells’ ability to halt the immune system so the body can fight back, it has not been effective in treating glioblastoma.
“He is a super-responder,” says Nassiri. “We saw him and talked to him not too long ago. He’s doing very well. He has no tumour on his MRI scan. It’s completely gone, and it has been gone for a very long time and he’s not on any treatment anymore. This is unchartered territory for us.”
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