Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine
, while providing the respective precursor drug as well as oxygen at a de facto unlimited uptake rate of 1,000 mmol per gTo determine species in microbiome models that were of importance for the microbiome’s combined potential to metabolize a drug, a shadow price analysis was performed as described previously. Briefly, shadow prices are a feature of every FBA solution that reflect the contribution of each metabolite in the model to the flux through the objective function.
Drug metabolites with over 50% nonzero entries were analyzed via linear regressions using heteroscedastic robust standard errors. First, we investigated potential effects of basic covariates via generalized linear regressions with the net production capacity being the response variable . Age and BMI were introduced into the models as restricted cubic splinesusing four knots resulting in three spline variables, each to test on potential nonlinear relationships.
Indonesia Berita Terbaru, Indonesia Berita utama
Similar News:Anda juga dapat membaca berita serupa dengan ini yang kami kumpulkan dari sumber berita lain.
Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases - Nature BiotechnologyModified CRISPR-based enzymes improve the prospect of inserting entire genes into the genome NatureBiotech
Baca lebih lajut »
Nature Biotechnology - SARS-CoV-2–human protein–protein interactomeThe January issue is live Our cover features a rendering of complexes between SARS-CoV-2 and human proteins, with interface mutations highlighted. See Zhou et al. & Kim et al.
Baca lebih lajut »
The next giant step for microbes - Nature BiotechnologyThe next giant step for microbes A microbiome therapy is approved by the FDA for treatment of Clostridioides difficile. What’s next?
Baca lebih lajut »
Nearly $7 million in unemployment benefits sent to Alabama inmates, dead people, state agency findsThe Alabama Department of Labor had inadequate verification procedures that failed to flag fraudulent claims, the report by the state Department of Examiners of Public Accounts found. Labor Department Secretary Fitzgerald Washington disputed the report.
Baca lebih lajut »
Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms - Nature BiotechnologyEngineered live bacteria suppress 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 infection in mouse lung and dissolve endotracheal-tube biofilms
Baca lebih lajut »
Nature Space has announced the departure of Roni from Xeed | allkpopOn January 17, 2023, Nature Space took to their Xeed Japan account to announce the departure of Roni from the group, effective as of January 16, 2023…
Baca lebih lajut »