Mapping the cells involved in endometriosis could improve our understanding of how genetics influences the risk of the condition and open the door to new drug targets
To look for genetic links, Lawrenson and her colleagues collected more than 400,000 cells from the pelvic tissue of 21 women aged between 21 and 62. Of these women, 17 had been diagnosed with endometriosis, with some cells being taken from their endometriosis-related lesions. The remaining four women had not been diagnosed with endometriosis and acted as the control group.
The map led to the team identifying a genetic mutation whose cellular effects could one day be an endometriosis drug target. The mutation appears to affect the lymphatic vessels that surround endometriotic lesions.“This work indicates potential routes and targets for investigation in endometriosis,” saysat the University of Edinburgh, UK. However, the endometriosis map is inconclusive given the study’s small sample size, she says.
Nevertheless, the research may enable us to better understand the cellular signatures of endometriosis, which could lead to novel treatment targets, she says.
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