The formation of the new liver-like organ in the lymph node may take several months.
A Pittsburgh-based biotech company has started a one-of-a-kind trial in a patient with a failing liver. Their goal is to grow a functional second liver within the patient’s body–something never achieved before. LyGenesis is currently carrying out a trial in only one patient with end-stage liver disease to test the efficacy of their allogenic regenerative cell therapy. , the experimental procedure was conducted in Houston on March 25.
“In a medical first, we have now dosed our first patient in a clinical trial using their own lymph nodes as living bioreactors to regenerate an ectopic organ,” said Dr. Michael Hufford, Co-Founder and CEO of LyGenesis. In this trial, scientists prepared donated hepatocyte cells for transplantation by suspending them in a solution. These cells were then transplanted into the patient’s upper abdominal lymph nodes, which are tiny bean-shaped structures. These structures are an essential immune system component and filter waste from the body.The team opted for a minimally invasive approach to inject the cells into the patient’s lymph node via a catheter in the neck.
In simplest terms, these cells have the ability to multiply over the next several months. In a person with a failing liver, lymph nodes might operate as a second liver-like organ. There is an increasing shortage of organs, thus scientists are looking for alternative techniques such as 3D bioprinting.
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