The monkeypox virus may potentially spread through FMT products, according to an FDA safety alert, and additional precautions are recommended.
issued this week by the US Food and Drug Administration . While the risk of such transmission is unknown, the agency said that additional safety protections are needed.
Monkeypox virus DNA has been detected in rectal swabs as well as in stool samples, according to recent studies. In one studyresearchers confirmed monkeypox exposure in three asymptomatic men from rectal swabs, and isolated viable viral DNA from two of those swabs. "This information suggests that monkeypox virus may be transmitted through FMT products, although the risk of such transmission is unknown," the agency stated. It is also not known if the monkeypox virus can spread through feces or from individuals with asymptomatic infections.
The FDA advised additional precautions for any investigational use of FMT involving stool donated since March 15, including: Donor screening targeted at identifying donors who are at high risk for monkeypox or who are currently or may have been recently infected with the virusInformed consent about the potential for the transmission of monkeypox virus via FMT from donors who may have asymptomatic monkeypox infectionClostridioides difficile
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