The FDA has expanded the indication of dapagliflozin to include treatment of HF across the full spectrum of LVEF ― including HFmrEF and with HFpEF. TwitteRx
In the trial, which included more than 6200 patients, dapagliflozin led to a statistically significant and clinically meaningful early reduction in the primary composite endpoint of cardiovascular death or worsening HF for patients with HFmrEF or HFpEFF.
In addition, results of a pooled analysis of the DAPA-HF and DELIVER phase 3 trials showed a consistent benefit from dapagliflozin treatment in significantly reducing the combined endpoint of CV death or HF hospitalization across the range of LVEF. The European Commission expanded the indication for dapagliflozin to include HF across the full spectrum of LVEF back in February,
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