FDA considering 'dose-sparing' approach to increase availability of Jynneos vaccine amid the expanding monkeypox outbreak
A vial of the Jynneos monkeypox vaccine at a pop-up vaccination clinic on August 3, 2022 in West Hollywood, California. Photo: Mario Tama/Getty Images
As the Department of Health and Human Services works with Jynneos' manufacturer to increase the availability of the vaccine, Califf said "dose-sparing" could provide a potential solution in the interim.The new approach would require a different method of administration, or injection into the skin, Califf said.
The new "dose-sparing" approach would require intradermal administration, which goes into the dermis. The dermis lies just underneath the top layer of skin known as the epidermis.
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