In his new autobiography, Matthew Perry reveals that his colon burst as a result of his addiction to opioid painkillers.
With long-term use, the drug's pain-relieving effects also decrease. As a result, doses are often increased.
in men. Hypogonadism occurs in women, too, but less commonly. The extent to which it is reversible is unclear.High-dose opioids cause reversible cognitive and behavioral changes. The sedative effect of the drugs impairs people's ability to pay attention and concentrate. The ability to experience pleasure diminishes, and people lose interest in activities. Social and family life can become more restricted or cease altogether. Although this type of behavioral change is often attributed to the underlying condition and pain rather than the stultifying effects of the medication.
Low doses work better than high doses, and some people fare better on no pain medication at all. With help, doses can be slowly tapered, but this is notoriously difficult once people are on high doses.Until now, it has been assumed that doses of opioids usually rise very slowly, which makes it difficult to realize that a problem is developing until it is too late., my colleagues and I looked at primary care records of all patients on high-dose opioids in a practice in Wales.
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