By taking aim at all 20 different types of influenza simultaneously, the scientists behind the new vaccine hope to provide at least some protection against all of the possible lineages.
"Our childhood infections, our first exposures to influenza virus, are super important for affecting how we respond to other influenza strains later in life," Hensley said.
Hensley said he would hope to eventually vaccinate a young child against all 20 different flu variants before age 5, providing them broad immune memory for a lifetime. Vaccinating animals that had already been exposed to influenza also provided broad protection, the study showed. "That is a longer-term goal to try to figure out what is the maximum number of antigens we can include in these vaccines. Can we have 50 antigens or 100 antigens?" Hensley asked. "These are some of the questions we're working on in my lab right now."Researchers are currently testing their experimental vaccine in nonhuman primates, after showing it worked successfully in mice and ferrets. Human trials could start as early as next year.
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