How many drinks is too much? According to a recent rodent study, even tiny amounts of alcohol may cause epigenomic and transcriptomic changes in brain circuitry in a region that is essential for the development of addiction. The pathways that are involved in setting the brain up for addiction, a
How many drinks is too much?
Subhash Pandey, director of the UIC Center for Research in Alcohol Epigenetics. Credit: Joshua Clark/University of Illinois Chicago “We’re seeing that dependent behaviors may not always be from long-term, high-quantity habits but a result of rapid epigenetic changes in the brain, which we show in this study may start happening even at low doses,” said Pandey, who is also a senior research career scientist at the Jesse Brown Veterans Affairs Medical Center.details Pandey’s experiments, which studied rats under control and alcohol exposure conditions.
Alcohol increased Hif3a expression, even after low doses of exposure, and reduced anxiety. And, while many effects of alcohol are different among males and females, there was no difference between the two in this study.
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