A Nature research paper identifies an immunosuppressive glycan-mediated mechanism that ensures feto-maternal tolerance during pregnancy
, Workflow. Plasma from non-pregnant or pregnant mice and humans was first run over species-specific Multiple Affinity Removal System columns to remove high abundance proteins, whose presence would obscure the detection of other glycopeptides. In one analysis , the MARS-depleted plasma was analyzed by mass spectrometry to identify endogenous proteins of potential placental origin bearing-linked glycans with terminal α-Sia.
identified 7 of the encoding genes to be likely expressed primarily if not exclusively by the conceptus. These genes and corresponding representative peptide species are shown in the table , and include
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