The investigational anti-amyloid drug donanemab significantly slowed cognitive and functional decline in a phase 3 study of adults with early symptomatic Alzheimer's disease, according to topline results hailed as highly encouraging by experts.
The investigational anti-amyloid drug donanemab significantly slowed cognitive and functional decline in a phase 3 study of adults with early symptomaticDonanemab met the primary endpoint, change from baseline until 18 months on the integrated Alzheimer's Disease Rating Scale , and all secondary endpoints measuring cognitive and functional decline, Eli Lilly saidIn the randomized, double-blind, placebo-controlled TRAILBLAZER-ALZ 2 trial, nearly half of patients taking donanemab had no...
"These are the strongest phase 3 data for an Alzheimer's treatment to date," Maria C. Carrillo, PhD, Alzheimer's Association chief science officer, said in a statement. The incidence of amyloid-related imaging abnormalities , a side effect of treatment, was consistent with the TRAILBLAZER-ALZ phase 2 study. The incidence of serious ARIA was 1.6%, including two participants whose death was attributed to ARIA and a third who died after an incident of serious ARIA.
"These are really encouraging results and show that targeting fundamental mechanisms in Alzheimer's can potentially make a difference to people's lives," said Malhotra.
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