Diving into deep-tissue imaging to help with cancer research

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Diving into deep-tissue imaging to help with cancer research
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Leonel Malacrida hopes that his lab’s imaging technology will advance cancer diagnosis and research in Uruguay and across Latin America.

Leonel Malacrida is a principal investigator at the Advanced Bioimaging Unit in Montevideo, Uruguay. Credit: Pablo Albarenga forI have always been interested in enzymes, membranes and other mechanisms of life. For my PhD at the University of the Republic in Montevideo I studied pulmonary surfactant, a biofilm in the lungs that allows people to breathe. But I then became very interested in advanced microscopy, which led me to do a postdoc in bioimaging at the University of California, Irvine.

In this image, I’m aligning a DIVER detector with a microscope I’m custom-building at the Advanced Bioimaging Unit in Montevideo, a joint venture between my university and the Pasteur Institute of Montevideo. I launched the unit in 2019, when I returned here after my postdoc, and Gratton licensed the DIVER technology to us so that we could build this device. It will be ready for use in a few months.

My main goal in designing and building the device is to help users examine metabolic fingerprints, or chemical patterns, in the lung, skin, kidneys and brain, among other organs. We expect to use it mainly in cancer diagnosis and research.

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